(AP) - The defending World Cup champions were soundly beaten in their opener for this year's tournament.
Robin van Persie and Arjen Robben both scored twice as the Netherlands crushed Spain 5-1 in a rematch of the last World Cup final. The Spaniards took a 1-0 lead in the 27th minute, but the Dutch tied it later in the first half before erupting for four goals in the second.
It was the worst loss for Spain in World Cup play since a 6-1 defeat to Brazil in 1950.
Mexico and Chile also won their World Cup openers.
Oribe Peralta scored in the 61st minute to lead Mexico's 1-0 triumph over Cameroon. The score would have been lopsided if Giovanni Dos Santos didn't have a pair of goals disallowed by questionable calls by the officials. Mexico and Brazil share first place in Group A, although the Brazilians have a better goal differential.
Alexis Sanchez and Jorge Valdivia scored just over a minute apart early in the first half to give Chile a 2-0 lead in a 3-1 victory against Australia. Chile threatened to run away with the game when Sanchez poked home from close range in the 12th minute before setting up Valdivia moments later. The outcome leaves Chile and Holland tied for the lead in Group B with three points, with the Dutch holding the tiebreaker.