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LOS ANGELES -- Oh, yes, he totally went there.

Russell Brand got right to the point during his opening monologue as host of Sunday's MTV Movie Awards. "I know the last time I did an MTV Movie Awards show I did end up marrying someone that was there," Brand said, referring to meeting estranged wife Katy Perry at the 2009 awards show. "So I will keep my eyes peeled for my next wife."

To kick things off at the Gibson Amphitheatre in Los Angeles, Brand joked about "vital issues," including Justin Bieber, who "beat up the paparazzi. Well done!" He also took on new couple Kim Kardashian and Kanye West. "I admire Kanye a lot. His drunken stage invasion of the last MTV Awards show I hosted took a lot of pressure off me." As for Kardashian, she "took a load of pressure off me with her world-record quick marriage. Cheers, Kim!"

And, in case the British comic does something to "jeopardize his green card," he said, he was grateful to have someone "more unstable and reckless than me to do something crazy ... That someone is obviously Charlie Sheen."

Sure enough, Sheen stood up to much applause.

"Of course, I'm actually here to promote 'Rock of Ages,'" Brand said, giving a shout-out to his upcoming film's co-stars, including Julianne Hough.

Jennifer Aniston, sleek and sexy in a leather minidress, took home the first golden popcorn of the night for "best dirtbag" for her performance in "Horrible Bosses."

The Amazing Spider-Man stars Emma Stone and Andrew Garfield presented Shailene Woodley with the award for breakthrough performance for her role in the Academy Award-nominated film "The Descendants."

For the fourth year in a row, the coveted award for best kiss went to "Twilight" stars and real-life couple Kristen Stewart and Robert Pattinson. "Rob's not here, you guys. I don't really know what to do!" said Stewart upon accepting the award. She tried to coerce Chris Hemsworth, Charlize Theron and Taylor Lautner to the stage, but when no one took the bait, Stewart said she does "really well by myself." She was also among cast members who accepted movie of the year award honors for "The Twilight Saga: Breaking Dawn - Part 1" at the end of the show.

Johnny Depp took home the highest honor: the MTV Generation Award. Aerosmith's Steven Tyler and Joe Perry presented the prize to Depp, who "has reinvented himself countless times," noted Tyler. He called the actor a "rock star in movies."

The award honored Depp for his contributions to the film industry and for entertaining generations of the MTV audience throughout his career.

The Black Keys performed a special rendition of their hit Gold On the Ceiling- and Depp himself got into the action, playing his guitar with the group.

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