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San Francisco, CA (Sports Network) - Vernon Davis' 23-yard touchdown reception late in the fourth quarter helped the San Francisco 49ers seal a 27-19 victory over the Detroit Lions at Candlestick Park on Sunday.

Davis finished with 73 yards and two scores on five catches for the 49ers, who were coming off an impressive 30-22 decision over the Green Bay Packers last week.

Alex Smith completed 20-of-31 passes for 226 yards and the two scores to Davis, while Frank Gore carried the ball 17 times for 89 yards and a touchdown for San Francisco (2-0).

Matthew Stafford went 19-for-32 through the air for 230 yards, a touchdown and an interception for Detroit (1-1), which never led in the game and could not recreate its dramatic, 27-23, come-from-behind victory over the St. Louis Rams in Week 1.

Calvin Johnson led all receivers with 94 yards on eight catches, and Kevin Smith had 53 yards on 16 carries in defeat.

It was the first meeting between the teams since Lions coach Jim Schwartz confronted 49ers coach Jim Harbaugh following San Francisco's 25-19 win in Week 6 of last season when Schwartz took exception to Harbaugh's hard handshake at the end of the game.

Schwartz nearly followed Harbaugh into his team's locker room and had to be restrained by members of his team, but there was no such incident at the end of this contest as the coaches cordially shook hands and walked away.